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AboutPricing
Drug ReportsMycophenolic acid
Mycophenolic acid
Mycophenolic, Myfortic (mycophenolic acid) is a small molecule pharmaceutical. Mycophenolic acid was first approved as Myfortic on 2004-02-27. It is used to treat graft vs host disease and psoriasis in the USA. The pharmaceutical is active against inosine-5'-monophosphate dehydrogenase 1 and inosine-5'-monophosphate dehydrogenase 2.
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YTD
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
Mycophenolic, Myfortic (discontinued: Mycophenolic)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Mycophenolic sodium
Tradename
Company
Number
Date
Products
MYFORTICNovartisN-050791 RX2004-02-27
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
cellceptNew Drug Application2024-11-21
mycophenolate mofetilANDA2025-01-13
mycophenolic acidANDA2025-02-05
myforticNew Drug Application2024-07-23
myhibbinNew Drug Application2024-05-07
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
psoriasisEFO_0000676D011565L40
graft vs host disease—D006086D89.81
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L04: Immunosuppressants
— L04A: Immunosuppressants
— L04AA: Selective immunosuppressants
— L04AA06: Mycophenolic acid
HCPCS
Code
Description
J7518
Mycophenolic acid, oral, 180 mg
Clinical
Clinical Trials
1303 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Autoimmune diseasesD001327EFO_0000540M30-M36————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameMycophenolic acid
INNmycophenolic acid
Description
Mycophenolic acid is a member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases. It has a role as an antineoplastic agent, an antimicrobial agent, an EC 1.1.1.205 (IMP dehydrogenase) inhibitor, an immunosuppressive agent, a mycotoxin, a Penicillium metabolite, an environmental contaminant, a xenobiotic and an anticoronaviral agent. It is a gamma-lactone, a member of phenols, a monocarboxylic acid and a member of 2-benzofurans. It is functionally related to a hex-4-enoic acid. It is a conjugate acid of a mycophenolate.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)OC2
Identifiers
PDB—
CAS-ID24280-93-1
RxCUI—
ChEMBL IDCHEMBL866
ChEBI ID168396
PubChem CID446541
DrugBankDB01024
UNII IDHU9DX48N0T (ChemIDplus, GSRS)
Target
Agency Approved
IMPDH1
IMPDH1
Organism
Homo sapiens
Gene name
IMPDH1
Gene synonyms
IMPD1
NCBI Gene ID
3614
Protein name
inosine-5'-monophosphate dehydrogenase 1
Protein synonyms
IMP (inosine 5'-monophosphate) dehydrogenase 1, IMP (inosine monophosphate) dehydrogenase 1, IMPD 1, IMPDH 1, IMPDH-I
Uniprot ID
P20839
Mouse ortholog
Impdh1 (23917)
inosine-5'-monophosphate dehydrogenase 1 (P50096)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Myfortic – Novartis
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Estimated US medical usage
Mycophenolic acid
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 56,278 documents
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Safety
Black-box Warning
Black-box warning for: Cellcept, Mycophenolate mofetil, Myfortic, Myhibbin
Adverse Events
Top Adverse Reactions
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110,014 adverse events reported
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