Mycophenolic acid
Mycophenolic, Myfortic (mycophenolic acid) is a small molecule pharmaceutical. Mycophenolic acid was first approved as Myfortic on 2004-02-27. It is used to treat graft vs host disease and psoriasis in the USA. The pharmaceutical is active against inosine-5'-monophosphate dehydrogenase 1 and inosine-5'-monophosphate dehydrogenase 2.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| skin and connective tissue diseases | D017437 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Mycophenolic, Myfortic (discontinued: Mycophenolic)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cellcept | New Drug Application | 2024-02-21 |
| mycophenolate mofetil | ANDA | 2024-11-14 |
| mycophenolic acid | ANDA | 2024-10-22 |
| myfortic | New Drug Application | 2024-07-23 |
| myhibbin | New Drug Application | 2024-05-07 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| psoriasis | EFO_0000676 | D011565 | L40 |
| graft vs host disease | — | D006086 | D89.81 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J7518 | Mycophenolic acid, oral, 180 mg |
Clinical
Clinical Trials
1290 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney transplantation | D016030 | — | — | 20 | 52 | 55 | 122 | 28 | 263 |
| Leukemia | D007938 | — | C95 | 58 | 156 | 15 | 2 | 21 | 225 |
| Syndrome | D013577 | — | — | 30 | 83 | 7 | 3 | 11 | 120 |
| Graft vs host disease | D006086 | — | D89.81 | 16 | 38 | 13 | 6 | 7 | 70 |
| Recurrence | D012008 | — | — | 19 | 41 | 5 | 2 | 3 | 61 |
| Nephritis | D009393 | — | N05 | 1 | 19 | 18 | 9 | 12 | 58 |
| Lupus nephritis | D008181 | EFO_0005761 | — | 1 | 19 | 18 | 9 | 11 | 57 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 9 | 11 | 9 | 17 | 7 | 48 |
| Liver transplantation | D016031 | EFO_0010682 | — | 2 | 14 | 11 | 17 | 6 | 48 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 4 | 6 | 12 | 14 | 10 | 43 |
Show 119 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 45 | 119 | 7 | — | 16 | 168 |
| Lymphoma | D008223 | — | C85.9 | 32 | 110 | 6 | — | 15 | 148 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 30 | 88 | 12 | — | 9 | 126 |
| Myeloid leukemia | D007951 | — | C92 | 28 | 85 | 11 | — | 8 | 120 |
| Preleukemia | D011289 | — | — | 32 | 80 | 3 | — | 11 | 113 |
| Multiple myeloma | D009101 | — | C90.0 | 24 | 68 | 4 | — | 12 | 97 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 23 | 68 | 7 | — | 8 | 97 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 17 | 64 | 6 | — | 8 | 86 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 14 | 62 | 7 | — | 5 | 80 |
| Hematologic neoplasms | D019337 | — | — | 24 | 56 | 4 | — | 6 | 75 |
Show 73 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 16 | 29 | — | — | 2 | 40 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 15 | 25 | — | — | 2 | 35 |
| Plasmacytoma | D010954 | — | C90.3 | 7 | 23 | — | — | 5 | 32 |
| B-cell lymphoma | D016393 | — | — | 4 | 23 | — | — | 4 | 28 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 3 | 22 | — | — | 4 | 27 |
| Aplastic anemia | D000741 | HP_0001915 | D61.9 | 4 | 21 | — | — | 3 | 26 |
| T-cell lymphoma | D016399 | — | — | 5 | 20 | — | — | 4 | 26 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 8 | 10 | — | — | 2 | 17 |
| Myeloid leukemia accelerated phase | D015465 | — | — | 5 | 13 | — | — | 2 | 17 |
| Mycoses | D009181 | — | B35-B49 | 3 | 12 | — | — | 4 | 17 |
Show 153 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 3 | — | — | — | 3 | 6 |
| Islets of langerhans transplantation | D016381 | — | — | 1 | — | — | — | 2 | 3 |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | — | — | — | — | 2 |
| Astrocytoma | D001254 | EFO_0000271 | — | 2 | — | — | — | — | 2 |
| Chronic granulomatous disease | D006105 | EFO_0000338 | D71 | 1 | — | — | — | 1 | 2 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
| Germ cell and embryonal neoplasms | D009373 | — | — | 1 | — | — | — | — | 1 |
| Medulloblastoma | D008527 | — | — | 1 | — | — | — | — | 1 |
| Rhabdoid tumor | D018335 | — | — | 1 | — | — | — | — | 1 |
Show 13 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bone diseases | D001847 | — | M89.9 | — | — | — | — | 2 | 2 |
| Proteinuria | D011507 | HP_0000093 | R80 | — | — | — | — | 2 | 2 |
| Infertility | D007246 | HP_0000789 | — | — | — | — | — | 2 | 2 |
| Uveomeningoencephalitic syndrome | D014607 | Orphanet_3437 | H20.82 | — | — | — | — | 2 | 2 |
| Heart disease risk factors | D000082742 | — | — | — | — | — | — | 1 | 1 |
| Antibody formation | D000917 | — | — | — | — | — | — | 1 | 1 |
| Choroidal neovascularization | D020256 | — | — | — | — | — | — | 1 | 1 |
| Pathologic neovascularization | D009389 | — | — | — | — | — | — | 1 | 1 |
| Scleritis | D015423 | HP_0100534 | H15.0 | — | — | — | — | 1 | 1 |
| Lysosomal storage diseases | D016464 | — | — | — | — | — | — | 1 | 1 |
Show 22 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Mycophenolic acid |
| INN | mycophenolic acid |
| Description | Mycophenolic acid is a member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases. It has a role as an antineoplastic agent, an antimicrobial agent, an EC 1.1.1.205 (IMP dehydrogenase) inhibitor, an immunosuppressive agent, a mycotoxin, a Penicillium metabolite, an environmental contaminant, a xenobiotic and an anticoronaviral agent. It is a gamma-lactone, a member of phenols, a monocarboxylic acid and a member of 2-benzofurans. It is functionally related to a hex-4-enoic acid. It is a conjugate acid of a mycophenolate. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)OC2 |
Identifiers
| PDB | — |
| CAS-ID | 24280-93-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL866 |
| ChEBI ID | 168396 |
| PubChem CID | 446541 |
| DrugBank | DB01024 |
| UNII ID | HU9DX48N0T (ChemIDplus, GSRS) |
Target
Agency Approved
IMPDH1
IMPDH1
Organism
Homo sapiens
Gene name
IMPDH1
Gene synonyms
IMPD1
NCBI Gene ID
Protein name
inosine-5'-monophosphate dehydrogenase 1
Protein synonyms
IMP (inosine 5'-monophosphate) dehydrogenase 1, IMP (inosine monophosphate) dehydrogenase 1, IMPD 1, IMPDH 1, IMPDH-I
Uniprot ID
Mouse ortholog
Impdh1 (23917)
inosine-5'-monophosphate dehydrogenase 1 (P50096)
Alternate
No data
Variants
No data
Financial
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Myfortic – Novartis
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Estimated US medical usage
Mycophenolic acid
Total medical expenditures per year (USD, in millions)
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Refill frequency
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 54,688 documents
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Safety
Black-box Warning
Black-box warning for: Cellcept, Mycophenolate mofetil, Mycophenolic acid, Myfortic, Myhibbin
Adverse Events
Top Adverse Reactions
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102,307 adverse events reported
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