Mycophenolic acid
Mycophenolic, Myfortic (mycophenolic acid) is a small molecule pharmaceutical. Mycophenolic acid was first approved as Myfortic on 2004-02-27. It is used to treat graft vs host disease and psoriasis in the USA. The pharmaceutical is active against inosine-5'-monophosphate dehydrogenase 1 and inosine-5'-monophosphate dehydrogenase 2.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| skin and connective tissue diseases | D017437 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Myfortic (generic drugs available since 2012-08-21)
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| graft vs host disease | — | D006086 | D89.81 |
| psoriasis | EFO_0000676 | D011565 | L40 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J7518 | Mycophenolic acid, oral, 180 mg |
Clinical
Clinical Trials
1267 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney transplantation | D016030 | — | — | 12 | 37 | 41 | 83 | 15 | 180 |
| Leukemia | D007938 | — | C95 | 20 | 65 | 3 | 1 | 10 | 89 |
| Graft vs host disease | D006086 | — | D89.81 | 13 | 34 | 8 | 3 | 6 | 55 |
| Lupus nephritis | D008181 | EFO_0005761 | — | 1 | 18 | 16 | 9 | 11 | 54 |
| Liver transplantation | D016031 | EFO_0010682 | — | 2 | 9 | 11 | 15 | 5 | 40 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 8 | 10 | 3 | 13 | 7 | 34 |
| Immunosuppression therapy | D007165 | — | — | 2 | 2 | 2 | 12 | 11 | 29 |
| Systemic lupus erythematosus | D008180 | HP_0002725 | M32 | 5 | 11 | 9 | 5 | 2 | 28 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 5 | 4 | 5 | 10 | 5 | 26 |
| Systemic scleroderma | D012595 | EFO_0000717 | M34 | 1 | 10 | 1 | 1 | 8 | 20 |
Show 65 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 45 | 111 | 5 | — | 15 | 157 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 29 | 78 | 12 | — | 9 | 116 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 22 | 60 | 7 | — | 8 | 89 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 17 | 58 | 4 | — | 8 | 78 |
| Lymphoma | D008223 | — | C85.9 | 15 | 52 | 2 | — | 9 | 71 |
| Multiple myeloma | D009101 | — | C90.0 | 16 | 46 | 4 | — | 8 | 67 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 12 | 51 | 6 | — | 5 | 67 |
| Hodgkin disease | D006689 | — | C81 | 15 | 48 | 5 | — | 7 | 67 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 10 | 52 | 4 | — | 6 | 66 |
| Mantle-cell lymphoma | D020522 | — | C83.1 | 5 | 28 | 3 | — | 4 | 36 |
Show 46 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Plasma cell neoplasms | D054219 | — | — | 7 | 23 | — | — | 4 | 31 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 13 | 20 | — | — | 2 | 29 |
| Aplastic anemia | D000741 | HP_0001915 | D61.9 | 3 | 16 | — | — | 2 | 20 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 3 | 15 | — | — | 4 | 20 |
| Anemia | D000740 | HP_0001903 | D64.9 | 8 | 13 | — | — | — | 18 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 8 | 10 | — | — | 2 | 17 |
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | 3 | 12 | — | — | 3 | 16 |
| Lymphomatoid granulomatosis | D008230 | — | C83.8 | 3 | 12 | — | — | 3 | 16 |
| Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 4 | 11 | — | — | 2 | 15 |
| Extranodal nk-t-cell lymphoma | D054391 | — | C86.0 | 3 | 11 | — | — | 3 | 15 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 16 | — | — | — | 2 | 18 |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | — | — | — | — | 2 |
| Chronic granulomatous disease | D006105 | EFO_0000338 | D71 | 1 | — | — | — | 1 | 2 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
| Germ cell and embryonal neoplasms | D009373 | — | — | 1 | — | — | — | — | 1 |
| Medulloblastoma | D008527 | — | — | 1 | — | — | — | — | 1 |
| Ependymoma | D004806 | — | — | 1 | — | — | — | — | 1 |
| Choroid plexus neoplasms | D016545 | EFO_0007206 | — | 1 | — | — | — | — | 1 |
| Primitive neuroectodermal tumors | D018242 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Islets of langerhans transplantation | D016381 | — | — | — | — | — | — | 2 | 2 |
| Heart disease risk factors | D000082742 | — | — | — | — | — | — | 1 | 1 |
| Bone diseases | D001847 | — | M89.9 | — | — | — | — | 1 | 1 |
| Death | D003643 | PATO_0001422 | — | — | — | — | — | 1 | 1 |
| Antibody formation | D000917 | — | — | — | — | — | — | 1 | 1 |
| Choroidal neovascularization | D020256 | — | — | — | — | — | — | 1 | 1 |
| Scleritis | D015423 | HP_0100534 | H15.0 | — | — | — | — | 1 | 1 |
| Lysosomal storage diseases | D016464 | — | — | — | — | — | — | 1 | 1 |
| Nervous system diseases | D009422 | — | G00-G99 | — | — | — | — | 1 | 1 |
| Proteinuria | D011507 | HP_0000093 | R80 | — | — | — | — | 1 | 1 |
Show 18 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Mycophenolic acid |
| INN | mycophenolic acid |
| Description | Mycophenolic acid is a member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases. It has a role as an antineoplastic agent, an antimicrobial agent, an EC 1.1.1.205 (IMP dehydrogenase) inhibitor, an immunosuppressive agent, a mycotoxin, a Penicillium metabolite, an environmental contaminant, a xenobiotic and an anticoronaviral agent. It is a gamma-lactone, a member of phenols, a monocarboxylic acid and a member of 2-benzofurans. It is functionally related to a hex-4-enoic acid. It is a conjugate acid of a mycophenolate. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)OC2 |
Identifiers
| PDB | — |
| CAS-ID | 24280-93-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL866 |
| ChEBI ID | 168396 |
| PubChem CID | 446541 |
| DrugBank | DB01024 |
| UNII ID | HU9DX48N0T (ChemIDplus, GSRS) |
Target
Agency Approved
IMPDH1
IMPDH1
Organism
Homo sapiens
Gene name
IMPDH1
Gene synonyms
IMPD1
NCBI Gene ID
Protein name
inosine-5'-monophosphate dehydrogenase 1
Protein synonyms
IMP (inosine 5'-monophosphate) dehydrogenase 1, IMP (inosine monophosphate) dehydrogenase 1, IMPD 1, IMPDH 1, IMPDH-I
Uniprot ID
Mouse ortholog
Impdh1 (23917)
inosine-5'-monophosphate dehydrogenase 1 (P50096)
Alternate
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Variants
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Financial
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Myfortic – Novartis
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Estimated US medical usage
Mycophenolic acid
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 51,208 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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76,687 adverse events reported
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